Revitalizing COPD Management: Exploring Drug Repurposing as a Promising Therapeutic Paradigm

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a prevalent and debilitating respiratory condition, necessitating ongoing exploration for innovative therapeutic strategies. This comprehensive review delves into the realm of drug repurposing as a promising avenue to expand therapeutic options for managing COPD. The pursuit of novel COPD treatments has prompted researchers to reassess existing drugs approved for other indications, leveraging their established safety profiles and mechanisms of action. Within this review, we examine a spectrum of repurposed drugs, including anti-inflammatory agents, bronchodilators, antioxidants, and more, shedding light on their potential benefits in COPD management. Additionally, we discuss clinical trials and real-world evidence supporting the efficacy and safety of repurposed drugs in COPD, emphasizing the urgency of finding cost-effective solutions to alleviate the socioeconomic burden of COPD. This review provides a comprehensive overview of the current state of drug repurposing in COPD therapy, highlighting its potential to enhance patient care and alleviate the global burden of this chronic respiratory ailment.