Gastroretentive drug delivery system – an overview

Abstract

Gastro-retentive drug delivery system (GRDDS) is one of the novel approaches in the field of oral sustained release drug delivery. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. Different innovative approaches like high density (sinking), floating, bio- or mucoadhesive, expandable, unfoldable, super porous hydrogel and magnetic systems, magnetic field assisted gastro-retention, plug type swelling system, muco-adhesion technique, floating system with or without effervescence are being applied to fabricate GRDDS. The present review mainly focuses on features and various physiological considerations for development of GRDDS.