Wound healing potential of naturally synthesized silver nano-particles

Abstract

Nanoparticles have been in raising demand in many fields of science and biotechnology and extends its applications in biomedical and pharmaceutical areas. Out of all the metals silver leads the way in this technology in view of its practical applications. They are used to preserve, diagnose many diseases and mainly used in external applications on the body emphasizing their antimicrobial and healing abilities. On the other hand, the synthesis of nano particles has been a very serious concern due to its huge cost of production, toxicity and dosing issues. Bio synthesis or green synthesis using herbals and microbes to synthesize nano particles showed a path to overcome the above hurdles and make the synthesis of silver nanoparticles more commercial and can be adopted on large scale. In this research silver nano particles were synthesized using purified extracts of leaves of Lannea coromandelica and were confirmed using UV spectroscopy. The produced nanoparticles exhibited surface plasmon resonance at 420nm in UV spectroscopy. They were investigated for their wound healing activity in excision wound model in wistar albino rats for a 16 day study. These nano particles were found to be very successful and showed wound healing property. Thus produced nano particles showed similar activity competent enough with that of the standard, Betanidine. These silver nano particles can be used efficiently in therapies that target infections and wounds that are provoked and delayed healing due to infections.