Methods on employed in screening of antiulcer drugs - an overview

Abstract

Peptic ulcers are caused by imbalance between the gastro duodenal mucosal defensive factors such as bicarbonate, mucus versus aggressive factors like acid and pepsin secretion. The drug treatment of peptic ulcer has significantly brought down the morbidity and mortality and need of surgical interventions which may be attributed to the advent of H2 blockers and proton pump inhibitors. These symptoms frequently occur several hours following a meal, after the food leaves the stomach but while acid production is still high. Instead of pain, some patients experience intense hunger or bloating. Many animal models are using to induce ulcer to identify the antiulcer property of many new and existed drugs such as Pyloras ligated rat, Stress ulcers, Histamine induced gastric ulcers, Cysteamine induced duodenal ulcers, Dulcerozine induced duodenal ulcers, Duodenal ulcers following Infusion of pentagastrin and carbacol, Indomethacin and histamine induced duodenal ulcers, MPTP induced duodenal ulcers. The above all induced types are useful experimental model for the research.