Development of New Spectrophotometric Methods for the Determination of Perindopril in Pharmaceutical Dosage Forms

Abstract

Three simple and sensitive Spectrophotometric methods have been developed for the determination of Perindopril (PDL) in pure and pharmaceutical dosage forms. Method A is based on the formation of Ion-assosiation complex of the drug with Bromothymol Blue (λmax: 415 nm). Method B is based on the formation of charge transfer complex of the drug with chloranilic acid (λmax: 580 nm). Method C is based on oxidation of the drug under alkaline conditions by oxidizing agents like potassium permanganate and subsequent formation of cherry red colored chromogen (λmax : 609 nm). These methods have been statistically evaluated and found to be precise and accurate.