FORMULATION AND EVALUATION OF LOSARTAN LOADED PROLIPOSOMAL GELS

Abstract

The main objective of the study was to formulate & evaluate Losartan loaded proliposomal gel for the treatment of hypertension. Various formulations of proliposomal gels were prepared by using thin film deposition technique using different ratios of lipid phase composition in rotary evaporator. The surface morphology of proliposomes was performed by Scanning electron microscope. All the formulations (PLGF1 to PLGF6) were characterized for entrapment efficiency which ranges from 99.4±0.02 to 99.7±0.02. Drug Loading was found to be 12±0.32 to 22±0.42. The Vesicle size of all formulations ranges from 5.12µm to 6.54 µm. The Physical examination of proliposomal gels were evaluated and all the formulations was found to be semisolid and pale yellow in colour, pH of all formulation ranges from pH 5.5 to 7.0. Viscosity ranges from 10700cps to 11200cps with drug content 80% to 94%. The mucoadhesive force of all formulation ranges from 2.5mints to 4.5mints. Among all the formulations PLGF5 showed maximum percentage of drug release i.e 98.48% with zero order kinetics.