HEPATOPROTECTIVE ACTIVITY OF CAULIFLOWER LEAF EXTRACT AGAINST ISONIAZID AND RIFAMPICIN INDUCED TOXICITY IN ALBINO RATS

Abstract

The most common complication of widely used antitubercular drugs like isoniazid and rifampicin was hepatotoxicity. The main purpose of the present study was to evaluate the hepatoprotective activity of cauliflower ethanolic leaf extract against a rat model of INH- RMP induced hepatotoxicity. In this study the hepatoprotective activity of ethanolic extract of cauliflower leaf (EELC) was determined by estimating the serum parameters like AST, ALT, ALP, bilirubin, cholesterol, triglycerides and total serum proteins. Preliminary pytochemical studies revealed the presence of phytoconstituents like alkaloids, flavanoids, steroids, carbohydrates, proteins, tannins, glycosides, saponins, thiols, phenols, triterpenoids and purins. Silymarin and EELC 200 and 400 mg/kg when administered to rats exhibited protection against RMP-INH induced hepatotoxicity as manifested by the reduction in toxin mediated rise in serum enzymes (AST, ALT, ALP, bilirubin, cholestrol, triglycerides) and increased total protein levels. The significantly increased percentage inhibition of DPPH and lipid peroxidation scavenging activity with EELC was noticed. The histopathological studies also revealed the preservation of liver integrity in treated groups.