FORMULATION AND EVALUATION OF CINNARIZINE FLOATING EXTENDED RELEASE MATRIX TABLETS

Abstract

In the present research cinnarizine floating tablets was developed to improve the solubility and bioavailability of BCS class-II drug (low solubility with high permeability). Solubility of cinnarizine depends on gastrointestinal pH and was found to have appreciable solubility in gastric pH when compared to intestinal pH. Hence in the present investigation, floating tablets of cinnarizine was developed to improve the bioavailability by increasing intrinsic solubility at acidic pH and drug release was extended to improve the patient compliance using different grades of HPMC (E15 & K4M) in different ratios. Six formulations CNZ-1 to CNZ-6 were prepared and evaluated for various physico-chemical parameters. Results of pre and post compression parameters revealed that, there is no incompatibility between drug and excipients and found to be within the limits. Optimum drug release profile in seen in CNZ-6 with 97.3% drug release in 10 hrs. Various kinetic models were fitted to the obtained data and the results indicates zero-order release (R2-0.99, n-0.97) which can be achieved when drug diffusion is rapid compared to the constant rate of solvent induced relaxation and swelling in the polymer.