International Journal of Pharmacometrics and Integrated Biosciences

Cytotoxicity of Anagallis arvensis L. Extracts: Implications for Traditional Healing

Nithyakalyani K, Voleti Vijayakumar, Nandhini M, Harini R R, Pavitra J — Mon, 27 Nov 2023 16:26:29 +0000

Anagallis arvensis L. comprises two species, specifically Anagallis foemina Mill. For centuries, the Navarra region in Spain has employed primulaceae as traditional wound healing remedies. Previous studies have established the antimicrobial and COX-inhibitory properties of this species. However, despite the known cytotoxic effects at high doses or with prolonged oral administration, there is a lack of definitive research to establish their toxicity. In this study, cytotoxicity was assessed using spectrophotometric methods, including the MTT and LDH assays, on PC12 and DHD/K12PROb cells. Notably, DHD/K12PROb cells exhibited heightened sensitivity to the extracts compared to PC12 cells, resulting in reduced cell survival and increased cell damage (LDH release). Significant reductions in cell survival were observed with methanol extracts exceeding 80 mg/ml. These findings suggest that the reported toxic effects in traditional medicine may be attributed to the cytotoxic nature of these plants.

3D printing technology in pharmaceutical science

Jakke Vyshnavi, Yerikala Ramesh, P Venugopalaiah, Y Prapurna Chandra — Mon, 27 Nov 2023 16:36:31 +0000

Multi printers (3dp) are indeed an innovative tech that permits its fakery like custom-fit substances, equipment, but also body parts a certain conference a private patient’s prerequisite. Thus, this has tremendous potential complete bring on a major conversion inside the pharm as well as health care. 3D printing technology encompasses this same producer-like formation of wanted to create whilst also condensation-like printers’ stuff in a layer-by-layer dress. This enables on-demand manufacturing-like systems with high performance. Nowadays, it's employed in several health care including profiling, implantable implants, morphological brands, synthetic biology as well as cell therapy, and orchestrated cell brands, but instead dental care. The first unbiased of all this summary is to explain different methods of precision medicine, advancement along delivery systems but also systems, 3D printing technology methodologies, use of polymer matrix through 3D printing technology, but instead adjustment yeah 3D printing technology throughout drug makers. Researchers additionally define recent versions there in falsification like repeated tasks profiling as well as based drug delivery processes as well as make a comparison a 3D printer as for biomaterials. Last but, researchers discuss the challenges, regulations elements, as well as emerging outcomes after all 3Dprinter’s Technology in Medical Configuration.Top of Form

Recent Advances in Biopharmaceuticals: Expanding the Therapeutic Arsenal for Disease Treatment

Anushiya M, Selvi G — Fri, 24 Nov 2023 00:00:00 +0000

Recent advancements in biopharmaceuticals have brought about a paradigm shift in disease treatment, expanding the therapeutic arsenal available to patients. Biopharmaceuticals, derived from living organisms or produced through biotechnology processes, have revolutionized medicine by offering targeted therapies and immunotherapies. Monoclonal antibodies have proven to be game-changers in various disease areas, while mRNA vaccines have revolutionized infectious disease prevention. Gene therapies and CAR-T cell therapies are correcting genetic defects and unleashing the power of the immune system against cancer. Biosimilars have increased access to biologic medications, and novel delivery systems are improving drug administration. Personalized medicine tailors treatments to individual patients, optimizing outcomes. Advances in manufacturing and quality control ensure safety, efficacy, and scalability. Despite regulatory challenges, the future of biopharmaceuticals holds promise, with ongoing research and development paving the way for novel therapies and improved patient care.