Effect of Pregabalin Against Aluminium Chloride Induced Neurotoxicity in Male Albino Wistar Rats

Abstract

Pregabalin ((S)-(amino methyl)-5-methylhexanoic acid) or (S-(+)-3- isobutylgaba), is a chiral branched-chain neutral amino acid. It was first synthesized as a racemate in 1989. Pregabalin (PGB) a gabapentin derivative had a wide variety of pharmacological activities such as anti-epileptic activity, it is beneficial in the partial onset seizures, painful diabetic neuropathy, and post hepatic neuralgia pain and in many non-epileptic conditions, including bipolar disorder, anxiety, alcohol, benzodiazepine dependence, hot flashes, neuropathic purities, central post-stroke pain, and chronic pain in adult patients and trigeminal neuralgia, migraine, reflex sympathetic dystrophy, and prophylaxis of chronic daily headache with analgesic overuse. The aim of the present study is to evaluate the effect of Pregabalin on aluminium chloride induced oxidative stress and neurotoxicity in rats. In this study aluminium chloride treated animals had shown anxiety like behavior. AlCl3 increased the overall time spent in closed arm and animals took more time to cross the closed arm to open arms in elevated plus maze. Therefore, pregabalin had shown anxiolytic activity against the AlCl3 induced anxiety like behaviour in rats. These contemporary results were collaborated with the former reports of pregabalin as an anxiolytic agent. Pregabalin accomplished as neuroprotective agent by attenuating the neuronal loss in DG, CA1, CA3 and cortex regions of rat brain caused by AlCl3 and had shown more potent anti-oxidant, antiacetylcholinesterase, neuroprotective agent against AlCl3 neurotoxicity.