FORMULATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF NATEGLINIDE

Abstract

The study was carried out to design a prolonged release dosage form to be used for targeted and controlled release drug delivery, preparation of mucoadhesive microspheres containing nateglinide, which will help in releasing small quantities of drug, advantage for treating of diabetes mellitus. Slowly dissolving polymers for sustaining the release may be suitable for long-term therapy in controlled alleviation of clinical manifestation. Ethyl cellulose and Eudragit RSPO provide a potentially useful means of delivering drugs because they are stable, both physically and chemically amenable to preparation in large batches. However the present work is aimed to design and evaluation of mucoadhesive microspheres of nateglinide. In this present work the mucoadhesive microspheres of nateglinide were prepared employing 23factorial design by using Ethyl cellulose along with Eudragit rspo and hydroxy propyl methylcellulose K4M.