Hypolipidemic activity of parts of Luffa aegiptiaca in poloxomer induced hyperlipidemia

Abstract

Cholesterol and lipids are the major class of metabolites that are used to store high energy in the form of fats in the body. They are often stored in specific places in the system and some times misplaced in the bloodstream and other areas leading to metabolic disorders. The elevation in their quantities in serum is often termed as Hyperlipidemia. It affects most the worlds population adversely and is the causative factor for many comorbidities. Usually, medicinal plants exhibit the activities which are mainly due to the chemical constituents in them that are mostly phenols and flavonols. The plant Luffa aegiptiaca was investigated for its hyperlipidemic activity in high-fat diet-induced diabetes method. The results showed hyperlipidemic activity by lowering the lipid levels in the serum Four parts of the plant Luffa aegiptiaca were investigated for the antihyperlipidemic activity by extracting them with ethanol. These were tested for the lipid reducing property in the rat models induced by poloxamer drug. There was a successful induction of the Hyperlipidemia in the animals. The extracts showed a significant activity int his model. Fruits and leaves showed the best activity compared to other parts.