Comparision of antiepileptic property of various parts of datura

Abstract

Epilepsy is the most common of the neurological conditions that are widely affecting most of the population around the world. It is a condition on its own and a symptom of other neurological conditions too. It affects almost one per cent of the human population. Many synthetic drugs are produced to treat epilepsy effectively in various mechanisms. Few of them are Barbiturates like phenobarbitone and barbital sodium, hydantoin derivatives like Phenytoin, Sedatives and azepam derivatives like Diazepam etc. Many drugs treat epilepsy but are not devoid of side effects as discussed. So herbs are supporting the system of medicine to treat epilepsy but don't have side effects and adverse effects. There are a lot of herbs that are used to treat the disease on among them is Datura stromonium. In this work, the comparison between the antiepileptic property of the different parts of Datura was investigated, which included Flowers, Leaves, Stems and Fruits. The activity was investigated in electrical shock method to induce epilepsy. The brain enzymes were used as estimating parameters. Overall, the flowers showed very less activity compared to stems followed by fruits, and leaves of the plant Datura stramonium showed the highest activity.