C-Peptide compound analysis in type 2 diabetic patients

Abstract

In adults, a fragment of diabetic individuals with βcell autoantibodies has initially non Insulin requiring diabetes clinically performing as type 2 diabetes mellitus (T2DM), named latent autoimmune diabetes in maturity (LADA) which on later years requires Insulin. LADA is either unnoticed or misdiagnosed in many cases. The occurrence GAD autoantibodies and positive levels of C-peptide analysis are tested to determine and finalize the patients’ Insulin dependency. The frequency of βcell autoantibodies (GAD) and C-Peptide analysis was determined in 31 Type 2 diabetic adults. The type of diabetes was classified by doing a Postprandial Blood Glucose test. Ten Type 1 diabetic patients and 10 ordinary people were also subjected to the three tests for comparative study. Twenty-three per cent of the adults with T2DM were tested positive for GAD autoantibody, and 61 per cent were tested positive (who came in T1DM range) for C-peptide analysis among them. 19% of the patients were tested positive for both GAD antibody and C-peptide analysis. Patients had the common symptoms of polyuria, polyphagia and polydipsia. In T2DM patients, 61% were females, and 39% were males, and all were non-obese. β‐cell autoantibodies were evident in a subcategory of initially non‐insulin needy diabetic adults with the clinical entrance of T2DM. This proves the existence and necessity for change in Insulin dependency.