Phylogenetically Analysis of Penicillin Related Genes at Fungi

Abstract

Antibiotics are valuable components that are being used for human health globally. Fungi, bacteria are such im- portant antibiotic producers. At the recent survey we have collected the DNA sequences of several fungal genera, penicillin antibiotic related genes (penDE, pcbC, pcbAB) from databanks and clustered by MEGA5 software. A se- quence comparison represents considerable similarities and differences at several levels, it could be considered as placement of each gene at different clade, sequence similaritiesbetween Penicillium and Aspergillus genera andbetween A. flavus and A. oryzae and also P. chrysogenum and P. nalgiovence. According to the importance of the antibiotics specially penicillin, it seems these similarities and differences could be a best candidate for the sub- sequent bioinformatics researches.