The effect of aqueous extracts of ceiba on stabilizing the hepatic enzymes

Abstract

Hepatotoxicity is the major physiological defect in the body that adversely effects the body and is responsible for the drug toxicity deposition. The liver is a large organ that helps to eliminate the toxins and eliminate the food toxins through metabolism through enzymes like cytochrome P450enzyme. The liver enzymes were altered due to the changes in liver function and integrity. But the liver tissue could regenerate itself, and any permanent damage to the tissue cannot be recovered. These drugs also cause damage to the liver tissue. The extraction solvents like methanol, ethanol and ether are very toxic and not considered safe. Even though they are dried up completely, there will be some traces remaining in the extracts. The study of the hepatoprotective activity of the extracts was performed in two methods like CCl4 and paracetamol method. The estimation of the liver enzymes was done to determine the hepatoprotective activity. The hepatoprotective herbs and the formulations incorporating their extracts have been patented too, and the use and applications have been significant. The extracts were tested in two doses, like 100 and 200. As it is seen, the 200mg/kg of the extract showed better activity compared to the standard drug and the extract at the lesser dose that is the 100mg/kg.