Bone markers in glucocorticoids induced osteoporosis

Abstract

Commonly glucocorticoids are used in the treatment of inflammatory, autoimmune disease, neoplasias, following organ transplantation. The prolonged uses of glucocoticoids decrease the bone formation, increase reasorbtion which leads to osteoporosis. The glucocoticoids induced osteoporosis is the second health problem in worldwide. Compare to other bone metabolic disease it is having no symptoms, suddenly cause bone fracture and therefore it is considered as “silent disease”. So, proper and rapid determination is needed for the diagnosis of the disease. Various bone markers are useful for determination and understading of bone metabolisim in osteoporosis pa- tients. In this article we discuss about the various bone markars and techniques that are usefull in early detection of osteoporosis. Among the various techniques available, the bone density is mainly used for the assessment of osteoporosis by using dual-energy X-ray absorptiometry (DEXA).