Evaluation of Antiulcer activity of kigelia africana, Sophora interrupta and Holoptelea integrifolia in rats

Abstract

Kigelia africana (Bignoniaceae), Sophora interrupta (Papilionaceae), Holoptelea integrifolia (Ulmaceae) are plants reported for their variety of ethnic medicinal value. To screen antiulcer activity of methanolic leaf extracts of these plants. Anti ulcer activity was evaluated in various animal models like aspirin induced and ethanol induced ulcer models in rats. Preliminary phytochemical studies revealed the presence of saponins, glycosides, alkaloids, flavonoids in the methanolic extracts of K.africana, S.interrupta, H.integrifolia. Further methanolic extracts at 200mg/kg (K.africana), 400 mg/kg (S.interrupta), 500mg/kg (H.integrifolia) p.o. doses significantly (P < 0.01) re- duced the ulcer score, ulcer number and ulcer index in aspirin induced and ethanol induced ulcer models in rats. The present study revealed the antiulcer activity of leaf extracts of K.africana, S.interrupta, H.integrifolia and the activities are due to the presence of phytochemical constituents such as saponins, flavonoids, as these phyto- chemical constituents were already reported for the above mentioned effects.