Effect of rutin and telmisartan on high fructose diet induced metabolic syndrome in ovariectomized female sprague dawley rats

Abstract

Metabolic syndrome will be treated with drugs like rutin and telmisartan on Ovariectomized plus high fructose diet induced metabolic dysfunction in SpraugueDawlyrats.The metabolic syndrome was induced by feeding the animals with Ovariectomized plus high fructose diet (HFD).Effect of telmisartan and rutin on Ovariectomized plus HFD induced metabolic syndrome for a period of 6 weeks. During this study period the weekly body weight varia- tion was determined. At the end of the study the animals were fasted for 24 h and blood sample was collected through retro orbital sinus. The plasma samples were used to estimate the biochemical parameters such as blood glucose, AST, ALT, urea, uric acid, creatinine, total cholesterol, triglyceride and HDL levels. At the day of the termi- nation, the experimental animals were sacrificed, organs were removed and absolute organ weight was meas- ured. In this present work we studied the effect of rutin and telmisartan on both vascular and metabolic parame- ters. Rutin is a Flavonoid glycoside having powerful anti oxidant as well as powerful anti-inflammatory property. In this study rutin and telmisartan were used to prevent the hepatic damage as well as metabolic dysfunction in rats. This study with support from ongoing clinical studies would be useful to standardize the standard dosage regimen or development of new selective PPAR γ modulators in metabolic dysfunction patients, for whom the treatment options are not satisfactory.Rutin shows promising effect on reactive oxygen species.