Two synergetic effects of Sonchus arvensis l. leaves decoction in calcium oxalate bladder stone therapy on male Wistar rat

Abstract

The anticalculi effect of Sonchus arvensis L. decoction on rat bladder stone has been done. The objective of the research is to determine its effect in bladder stone therapy. Bladder stone was done by matrix-glycolic acid induc- tion method, used silk string matrix which inserted by surgical in bladder and two day afterwards given per orally glycolic acid at the dosage 500 mg/kg BW/day during 7 days. Preventive group was treated with 1.30 mg/kg BW/day decoction. The curative group 8 days later received the same treatment during 8 days. The result was measured with the weight of bladder stone which was deposited on string matrix and were statistically analyzed by Student’s t-test. In prevention occurred 47.48% (p≤0.05) the inhibition effect. In curative occurred the inhibi- tion and dissolving effects of existed bladder stone 46.50% (p≤0.02) and 4.02% respectively. In conclusion two effects can be shown namely (1) preventive measure: by the inhibition effect, it inhibits the formation of bladder stone and (2) curative measure: by the inhibition of bladder stone enlargement and dissolving of existed bladder stone.