Betulin from bark of Betulautilis act as an anti-convulsant agent

Abstract

The present study was undertaken to explore the anticonvulsant activity of the 95% ethanolic extract of the bark of Betulautilis on male albino mice’s divided into three test groups which were given the graded doses of the dich- loromethane fraction of ethanol extract 100, 200 &300 mg/kg bodyweight respectively and 20 mg/kg body weight phenytoin solution as standard). The method used to induce the convulsion in mice’s was Maximal Electro-Shock (MES)-induced convulsions and the entire activity was recorded and analyzed properly to observe characteristic phases, i.e. Flexion, Extensor, Clonus, Stupor and Recovery / Death. Preliminary phytochemical screening revealed the presence of alkaloids, glycosides, carbohydrates, saponins, triterpenoids& flavonoids. It was seen that the ex- tract of bark of Betulautilis in a dose of 300 mg/kg body weight was found to possess maximum inhibition of sei- zure (88.93%) in comparison to all other doses and all other treatments given except standard drug (Phenytoin), showing 93.33% inhibition of seizure. So, It is concluded that plant (Betulautilis) seem to be promising candidates with respect to its anticonvulsant activity and may be used for controlling epileptic seizures.