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Abstract

Lipoproteins are a heterogeneous population of macromolecular aggregates of lipids and proteins that are re- sponsible for the transport of lipids through the vascular and extravascular fluids from their site of synthesis or absorption to peripheral tissues. Cells fulfill these requirements either from circulation, by synthesis through the metabolism or from degradation of major lipoprotein fractions like VLDL, LDL or HDL. Cholesterol is an essential constituent of lipoprotein fractions like LDL, HDL and VLDL. Seventy five percent of the plasma cholesterol is transported in the form of LDL- cholesterol. Cellular uptake and regulation of cholesterol is mediated by lipoprote- in receptors especially located on the surface of the cells. For transport in plasma, triglycerides and cholesterol are packaged into lipoproteins, which are then taken up and degraded by cells to fulfill demands for cellular functions. In some malignant diseases, blood cholesterol undergoes early and significant changes. Low levels of cholesterol in the proliferating tissues and in blood compartments could be due to the process of carcinogenesis. However, earlier studies have reported that hypolipidemia may result due to the direct lipid lowering effect of tumor cells or some secondary malfunction of the lipid metabolism or secondary to antioxidant vitamins. Several prospective and retrospective studies have shown an inverse association between blood lipid profile and different cancers. Low HDL- cholesterol is an additional predictor of cancer. Many researchers have reported inverse association of plasma/serum lipids and lipoproteins with different cancers. Thus lower plasma lipid status may be a useful indica- tor for initial changes occurring in neoplastic cells. The present article is a review highlighting findings about plas- ma lipid profile as predictor of cancer.

Keywords

Cancer cholesterol HDL LDL lipoproteins VLDL

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How to Cite
A.B, P., R.C, D., S.B, P., S.J, I., M.S, B., & N.M, B. (2015). Plasma lipid profile as predictor of cancer . International Journal of Research in Phytochemistry and Pharmacology, 5(3), 37-41. Retrieved from https://scienztech.org/index.php/ijrpp/article/view/875

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