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Acute toxicity studies in animals are usually necessary for any pharmaceutical intended for human use. The infor- mation obtained from these studies is useful in choosing doses for repeat-dose studies, providing preliminary identification of target organs of toxicity, and, occasionally, revealing delayed toxicity. Acute toxicity studies may also aid in the selection of starting doses for Phase 1 human studies, and provide information relevant to acute overdosing in humans. The present study was designed to investigate the acute and sub-chronic toxicities of the topical extract of mangifriaindica seed on Wistar albino rats. Toxicity study was carried out by using three differ- ent doses like 1, 2 and 4 mg/kg/day. Several parameters like aspartate transaminase, alanine transaminase, alka- line phosphatase, total protein, albumin, total bilirubin, direct bilirubin, urea, hemoglobin, red blood cell, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin concentration, white blood cell, lympho- cytes, granulocytes and histopathology of liver, kidney, heart and spleen. The extract in all the doses produced significant protection and offered the therapeutic profile related to Mangiferaindica extract.


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Awad El-Gied, A. A., Mahmoud, I. M., Mohammed, A., & Hamedelniel, E. I. (2013). Evaluation of Acute and Sub-Chronic Toxicities of the topical extract of Mangifriaindica Seeds on Wistar albino Rats. International Journal of Research in Phytochemistry and Pharmacology, 3(3), 149-154. Retrieved from