Fabrication and characterization of transdermal drug delivery using Losartan potassium

Abstract

The aim of the study was to develop suitable transdermal drug delivery system of Losartan potassium with a view to prevent its first pass hepatic metabolism, to achieve a controlled release drug and improved bioavailability. Hence, the present study was designed to develop a transdermal patch containing Losartan potassium using dif- ferent polymeric combinations such as hydroxy propyl methyl cellulose (HPMC K 100), Eudragit RL100 and Carbo- pol 930 (CP). The patches were subjected to physicochemical parameters, in-vitro, in-vivo drug release, stability studies and ex-vivo skin permeation studies .Good results were obtained in all the evaluated parameters. The drug release of all formulation follows zero order kinetics by diffusion mechanism of non fickian diffusion type. An Ex- vivo transdermal permeation study was performed using rabbit& goat skin. Good correlation has been obtained against both Exvivo and Invivo drug release with Invitro drug release. The formulation L8 was found to be stable at room temperature and refrigerator temperature. The developed transdermal delivery system containing Losartan Potassium might be a milestone in the hypertension.