Investigation of anti-arthritic potential of ethanol extract of Hibiscus platinifolius

Abstract

Rheumatoid Arthritis is an autoimmune disease which causes chronic inflammation in the joints n even affects the healthy tissues in the body because their immune system attacks their body's tissues. This process creates an inflammatory response of the synovium, which is synovitis secondary to hyperplasia of the synovial cells. In their research, Locally available plants are verified on their therapeutic use. Arthritis is an autoimmune disease which causes chronic inflammation in the joints n even affects the healthy tissues in the body because their immune system attacks their body’s tissue. In Literature survey, it is revealed that the plant Hibiscus platinifolius (Malvaceae) is used as an ethnic folklore medicine for arthritis than other medicinal use. Primary inflammatory response consists of swelling of oedematous with multiple joints mainly in hind paws then within hours; it develops at the inoculation site. Later it involves the development of inflamed peri articular swelling in the limbs and of erythematous nodules and segmental radial swellings and ridgings which encircling the tail adjacent to the intervertebral disks of the caudal vertebrae. According to the reports, it has shown that the formation of bone was broadly reduced while bone resorption was increased in arthritic disease. In blood and liver, the FA activity increases then N-acetyltransferase (NAT) activity and it shows the effect not only on the serum biochemical parameters like SGOT, SGPT and ALP but also on haematological parameters such as RBC, WBC, Hb% and ESR.