HEPATOPROTECTIVE ACTIVITY OF ECBOLIUM VIRIDE (FORSK.) ALST. (ACANTHACEAE) ON EXPERIMENTAL LIVER DAMAGE IN RATS

Abstract

The Methanol extract of Ecbolium viride (Forsk.) Alst. (Acanthaceae), was tested for hepatoprotective activity against carbon tetrachloride and paracetamol-induced hepatotoxicity in rats. Ecbolium viride (Forsk.) Alst. (Acanthaceae), exhibited significant hepatoprotective activity by reducing carbon tetrachloride and paracetamol-induced change in bio-chemical parameters that was evident by enzymatic examination. The plant extract may interfere with free-radical formation, which may conclude in hepatoprotective action. Acute toxicity studies revealed that the LD50 value is more than the dose of 5 g/kg body wt.