Pyrazole and 2-Pyrazoline Derivatives: Potential Anti-Inflammatory and Analgesic Agents

Abstract

The search for new analgesic and anti-inflammatory agents are gaining lots of attraction because of their importance in management of acute pain and inflammation as well as their utility in early phases of many serious disorders like Alzheimer’s dementia, cancer, heart vascular disease etc. In literature pyrazole and 2pyrazoline derivatives are reported to possess interesting profile of analgesic and anti-inflammatory activity. As well as number pyrazole derivatives have already found their application as NSAIDs clinically. In this review article it has been tried to collate the reported work by many researchers on the pyrazole and 2pyrazoline derivatives as analgesic and anti-inflammatory agents. The overview of various reported pyrazole and 2-pyrazoline derivatives claims that they are potentially active as analgesic and anti-inflammatory agentsThe search for new analgesic and anti-inflammatory agents are gaining lots of attraction because of their importance in management of acute pain and inflammation as well as their utility in early phases of many serious disorders like Alzheimer’s dementia, cancer, heart vascular disease etc. In literature pyrazole and 2pyrazoline derivatives are reported to possess interesting profile of analgesic and anti-inflammatory activity. As well as number pyrazole derivatives have already found their application as NSAIDs clinically. In this review article it has been tried to collate the reported work by many researchers on the pyrazole and 2pyrazoline derivatives as analgesic and anti-inflammatory agents. The overview of various reported pyrazole and 2-pyrazoline derivatives claims that they are potentially active as analgesic and anti-inflammatory agents