Main Article Content

Abstract

Floating matrix tablets of Cephalexin were prepared by using a combination of synthetic and natural polymers in two different concentrations. The floating properties and in-vitro drug release properties were optimized by 23 factorial design and total 8 formulations were developed. The synthetic and natural polymers used in combination were HPMC K4M, HPMC K15M and Xanthan Gum, Guar gum respectively. Each formulation consists of a combination of one synthetic and one natural polymer in any one ratio of 1:1 or 1:4. In this study it was confirmed that the formulations containing HPMC K4M, have shown better floating properties and finally the formulation containing a combination of HPMC K4M and Xanthan Gum in 4:1 ratio, has shown better in-vitro release properties.

Keywords

Floating matrix tablets, Cephalexin HPMC K4M Xanthan Gum Gastric retention.

Article Details

How to Cite
K, N. R., P, K., K, S., K, S., CH, S., M, N., & P, S. (2012). FORMULATION AND IN-VITRO EVALUATION OF FLOATING MATRIX TABLETS OF CEPHALEXIN . International Research Journal of Pharmaceutical and Applied Sciences, 2(2), 44-56. Retrieved from https://scienztech.org/index.php/irjpas/article/view/311