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Abstract
Floating matrix tablets of Cephalexin were prepared by using a combination of synthetic and natural polymers in two different concentrations. The floating properties and in-vitro drug release properties were optimized by 23 factorial design and total 8 formulations were developed. The synthetic and natural polymers used in combination were HPMC K4M, HPMC K15M and Xanthan Gum, Guar gum respectively. Each formulation consists of a combination of one synthetic and one natural polymer in any one ratio of 1:1 or 1:4. In this study it was confirmed that the formulations containing HPMC K4M, have shown better floating properties and finally the formulation containing a combination of HPMC K4M and Xanthan Gum in 4:1 ratio, has shown better in-vitro release properties.
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