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Ethanolic extract of Clerodendrum serratum Linn.,leaves (EECS) were evaluated for analgesic activity using Tail flick test and Acetic acid induced Writhing test. EECS at 250 mg/kg and 500 mg/kg were treated for 7 days and compared with diclofenc sod. 10 mg/kg single dose administered on 7th day before one hour of taking result. EECS at 250 mg/kg and EECS 500 mg/kg treated group showed highest significant (p<0.001) increase in latency time in tail flick test and protected no of writhing at 25.27% and 32.74% respectable. Both were comparable with standard diclofenc sod. 10 mg/kg. in both test models. The results of the present study support the folklore use of this plant in pain
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