DEVELOPMENT AND EVALUATION OF NOVEL COMPRESSION COATED TABLETS OF LEVOFLOXACIN AND RABEPRAZOLE USED IN THE TREATMENT OF PEPTIC ULCER DISEASE

Abstract

Objective of present Study is to develop floating core in coat tablet in treating peptic ulcer disease. Rabeprazole and levefloxacin was used as model drug. The powder or granular bed is evaluated for pre compressional characteristics. The core tablet containing rabeprazole is prepared by direct compression and the coat granules containing leveofloxacin is prepared by wet granulation method, core tablet is compression coated with levofloxacin granules. The tablet is evaluated for compressional characteristics like thickness, diameter, hardness, buoyancy, floatation duration and studied in vitro dissolution in SGF and SIF in modified dissolution apparatus and studied the effect of different diluents like mannitol and MCC on release of rabeprazole in core tablet, HPMCK4M, Guar gum, Xanthan gum diluents on levofloxacin release in coat. The release of rabeprazole in Cr 2 is grater than Cr 1 because the mannitol is hydrophilic absorbs water and higher dissolution. The release of levofloxacin from coat containing HPMC K4M is higher by burst effect fallowed release in guar gum offering lesser resistance to molecular path than Xanthan gum. The above results indicate that floating core in coat tablet containing Guar gum and Xanthan gum as diluents are potential in the treatment of peptic ulcer disease.