A REVIEW: ANIMAL MODELS USED IN THE SCREENING OF ANTIEPILEPTIC DRUGS

Abstract

Animal models for seizures and epilepsy have played a fundamental role in advancing our understanding of basic mechanisms underlying epileptogenesis and have instrumental in the discovery and preclinical development of novel antiepileptic drugs. This paper reviews the invivo models like the electrically induced convulsion (e.g. maximal electroshock, kindling) and chemoconvulsants (e.g. strychnine, pentylenetetrazole, picrotoxin, isoniazid, lithium pilocarpine, yohimbine, bicuculline, 4aminopyridine and penicillin), invitro and genetic model for seizures and epilepsy.