IFN-γ AND PROSTATE SPECIFIC ANTIGEN (PAS) HOW NEW BIOMARKERS FOR IMPROVE EARLY DETECTION OF PROSTATE CANCER

Abstract

Prostate cancer may be the most common cause of cancer among men. The triage by digital rectal examination (DRE) and prostate specific antigen (PSA) exam reduces the incidence of the disease. The PSA is a specific marker of the organ, but has low specificity, making it necessary to search for new biomarkers to diagnosis. Among these, highlight the cytokines. There is a correlation between pro-inflammatory cytokines and increased production of PSA. IFN-γ can be seen as a key factor in the pathogenesis of prostatic diseases and may auxiliary in the diagnosis as a possible biomarker. The aim of this study was to investigate the relationship between IFN-γ and PSA levels. The study was conducted with 113 men from Brazilian Legal Amazon. The concentrations of IFN-γ and PSA were measured by Enzyme Linked Immunosorbent Assay (ELISA). The IFN-γ concentration was higher in individuals with PSA alterations. In conclusion, measurements of serum IFN-γ levels may be new marker provide additional for prognostic information to altered PSA in male serum and contribute to man's health.