ISOLATION AND NEPHROPROTECTIVE ACTIVITY OF BUTRIN FROM ALCOHOLIC FLOWER EXTRACT OF BUTEA MONOSPERMA

Abstract

Butea monosperma (fabaceae) is use ayurveda for treatment of inflammation, liver disorders, epilepsy , wound healing, diarrhea, diabetic activities. It is also known as modugu in telugu. The presenr study was under taken to evaluate the nephro protective activity of butrin alcoholic flower extract Butea monosperma using gentamicin , cisplatin ,cyclosporine induced methods and reperfusion induced ischemia of rat kidney methods. The comparative histopatholigcal study of kidney exhibited almost normal architecture as compared to control group. Action showed by Butrin (10 mg/kg, 20 mg/kg) was by dose dependent manner that BT 20 mg /kg was more significant in normalizing the toxicity caused by gentamicin, cisplatin and cyclosporine and I/R. The result obtained show that the alcoholic extract of Butea monosperma posses significant nephroprotective activity.