EMULSOMES: A NOVEL LIPOSOMAL FORMULATION FOR SUSTAINED DRUG DELIVERY

Abstract

Today a huge problem of poorly water soluble is faced in the world. Nowadays many methods are there for increasing the solubility, among them lipid technology is the most prominent and recent technology. At present , the available drug delivery system do not behave ideally, but now a days sincere attempts are going on to achieve them through various novel drug delivery system. Vesicular drug delivery system are selected to overcome problems such as poor drug bioavailability ,protect drug from harsh gastric environment and gastric enzymes and it provides an efficient way for delivery of drug to site of injection, hence decreasing the toxicity and also the adverse effect associated with it. Emulsomes are prepared as novel lipoidal vesicular system with internal solid fat core surrounded by Phospholipid bilayer and this acts as a carrier and vehicle of choice for poorly soluble drugs . Emulsomal based formulations of genetic drugs such as plasmids and antisense oligonuclieotides which are used for gene therapy have good systemic utility and are easily available. Recently the technology have been extensively studied in the aim of improving the efficacy of drug release and also to increase the selectivity of the drugs .It has a wide range of therapeutic application in case of parental drug delivery, gene therapy and also oral formulations. This review addresses about the success of emulsomal drug delivery system and special attention has been focused on advantages, disadvantages, structure, composition, method of preparation, application and various aspects related to emulsomal drug delivery.