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Abstract
Ipomoea Pes-caprae(L.) R.Br (IP)distributed in the tropics and subtropics regions is used in folk and tribal medicines.
Traditionally IP was used to treat arthritis, pain, ulcer, cancer and wounds. The present study aims to discover the anti-ulcer effect
of ethanolic extract from stems of IP (EESIP) at doses 200 mg/kg & 400 mg/kg in aspirin and pylorus ligature induced gastric
ulcer models in terms ofprotection from lipid peroxidation and the antiulcer activity as seen by the area of gastric lesions, gastric
juice volume, gastric pH, total acidity and total adherent gastric mucus content. Ranitidine (27 mg/kg) was used as the standard.
Preliminary phytochemical study of EESIP revealed the presence of alkaloids, carbohydrates, glycosides, flavonoids, tannins,
sterols and terpenoids. The LD50 ofEESIPwas found to be >2000 mg/kg by acute oral toxicity study. EESIP produced dose
dependent and significant anti-ulcer activity when compared to control group animals. Presence of flavonoids, tannins, sterols and
terpenoids may be responsible for the anti-ulcer activity of EESIP.
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