CONDUCTOMETRIC DETERMINATION OF CERTAIN PHARMACOLOGICAL DRUGS USING SILVER AND BISMUTH

Abstract

Two simple, rapid and accurate conductometric methods were developed for determination of losartan potassium,
pantoprazole sodium, sumatriptan succinate, rabeprazole sodium and lomefloxacine HCl in pure form as well as in their
pharmaceutical formulations. The proposed methods based on using two different precipitating agents for conductometric
determination of the cited drugs. Method (A) based on reaction of losartan potassium, pantoprazole sodium, sumatriptan
succinate and rabeprazole sodium with silver nitrate forming a white precipitate. Method (B) based on reaction of lomefloxacine
HCl, pantoprazole sodium and sumatriptan succinate with bismuth tetraiodide, forming an orange red precipitate. Different
factors affecting the reaction as concentration of both silver nitrate and bismuth tetraiodide, type of solvents used and also
formation of the bismuth tetraiodide were carefully studied to obtain the best results. The described procedures allowed the
determination of the studied drugs in the range of 5-15mg/50 mL for (method A) and 0.5-10mg/50mL for (method B). The
proposed methods were validated and successfully applied for the determination of the studied drugs in pure form and in their
pharmaceutical preparations. The obtained results were statistically compared with reference methods and no significant
differences were found.