MECHANISMS AND PERCENT OF DRUG RELEASE OF EACH NEW MATHEMATIC APPROACH

Abstract

Peppas and Sahlin model accounts for the coupled effects of Fickian diffusion and case II transport. By using the exponent coefficient (n) from Krosmeyer-Peppas model and substitution in Peppas-Sahlin model, the constants (K1&K2) could be calculated using different calculation methods. Matrix method is widely used for calculation of the kinetic constants which lead to calculate one constant value for each mechanism, for the whole drug release process. It was proved about the unacceptable points on using the kinetic constants (K1&K2) calculated by matrix solution method for comparison and also for calculation of the Fickian fraction release. Another mathematic method was applied for calculation of the kinetic constants (K1&K2) which is substitution method. The use of the substitution method gives the chance for calculation of the kinetic constants (K1&K2) at each unites time. As a result it could be calculate the amount of drug release % by each mechanism at each unites time and there is no need for further calculation for comparison like the Fickian fraction release. Also the substitution method may be, indicate the role of each drug release mechanism at each point especially because the comparison would be between the amount of drug release % by each mechanism at each unites time. Not only that but also the overlap, alternate, predominate and also combination of all drug release mechanisms at each unites time can be clearly observed which bring us to the realty of the drug release process which is a dynamic complex one.