FORMULATION AND EVALUATION OF EXTENDED RELEASE MONOLITHIC MATRIX TABLETS OF METOPROLOL SUCCINATE

Abstract

The present investigation was undertaken to fabricate once- daily extended release monolithic matrix tablets of Metoprolol succinate by direct compression method to overcome its side effects, to increase bioavailability, to reduce the dosing frequency and to improve the patient compliance. The tablets were prepared using xanthan gum. Prepared matrix tablets were evaluated for various parameters like hardness, friability, weight variation, percentage of drug content. Tablet formulations were subjected to in vitro drug release studies as per USP guidelines. The formulation containing drug: Xanthan gum ratio 1:1.5 offered the required in - vitro drug release according to the official limits of drug release as per USP. The economy of Xanthan gum & faster hydration rate favors its use in modified release tablets. Xanthan gum can effectively control the drug release for freely soluble drug in case of extended release formulations which are upcoming dosage forms for patient compliance in all aspects.