Underlying antioxidant activity in the anticonvulsant potency of polyherbal tonic

Abstract

Convulsions are the commonest of the symptoms that prevail in the most of the diseases that affect the human nervous system. Almost 1% of the world’s population now suffer from epilepsy as a long-term disease and had been on medication for an extended period of time. There are many investigations and theories advocating that the elevated enzyme activity in the brain and their inability to protect the brain from the free radical generation and normalization will lead to convulsions and seizures. There were investigations that the free radicals were counter acted by the protective enzymes in the brain there by preventing the convulsions. So with this assertion, the enzyme levels of the brain are an indicative for the estimation of the antioxidant extent and there by convulsant activity in the brain. In the current work, the prepared polyherbal tonic was investigated for the antioxidant activity by giving special emphasis to the antiepileptic activity of the herbs used in the tonic. The results proved that the prepared tonic was effective in normalizing the altered levels of enzymes and thereby proving that the antioxidant potency of the herbs helped in displayed the antiepileptic activity too. the tonic was effective at higher dose compared to low dose which shows a dose based antiepileptic activity.