FORMULATION AND IN-VTRO EVALUATION OF RAPIDLY DISINTEGRATING TABLETS OF RIZATRIPTAN BENZOATE

Abstract

Recent developments in rapidly disintegrating technology make tablets to disintegrate in the mouth without chewing and additional water intakes have drawn a great deal of attention. Rizatriptan benzoate is a selective serotonin receptor agonist and a potent anti-migraine drug with a bitter taste. Thus the taste has to be masked in order to reduce its bitterness, to increase its palatability and also to improve patient compliance. Therefore, attempts were undertaken to mask the bitter taste by using ion exchange resins Tulsion 339 as well as Eudragit E 100 and to formulate into RDT by adopting direct compression method by incorporating superdisintegrantsIndion 234, CCS and SSG in various concentrations. Precompressional studies revealed good micromeritic properties of powder blend for direct compression. Tulsion 339 complex (1:1) with 40 min swelling time at pH 3, stirred for 150 min showed maximum drug loading. Selected tablets (R4 and P4) containing Indion 234 exhibited quicker disintegration than CCS, SSG and were also found to be superior to marketed tablet with respect to disintegration and dissolution. The results revealed that Rizatriptan benzoate was successfully taste masked and formulated into as a RDT tablet.