Evaluation of the anti-hyperlipidaemic activity of Premna integrifolia using experimental animal model

Abstract

The present study was designed to evaluate the anti-hyperlipidaemic activity of Premna integrifolia using experi- mental animal model. Sprague Dawley rats weighing 200-300 gm of either sex were divided into 4 groups viz. Normal control; Cholesterol control (HFD); High Fat Diet (HFD) & Premna integrifolia (Agnimantha) (500 mg/ kg) treated; HFD & Atorvastatin treated (standard control). All groups were maintained on high fat diet for 30 days. Blood samples were collected after 30 days, for lipid estimation. High fat diet (HFD) caused significant increase in the serum Cholesterol, Triglyceride, VLDL, LDL & significant reduction in HDL level. Premna integrifolia & Atorvas- tatin treatment showed significant prevention in increased serum Cholesterol, Triglyceride, LDL as compared to cholesterol control (HFD) group. While HDL level was significantly increased in treated & standard group as com- pared to cholesterol control (HFD) group. From the above results, we conclude that Premna integrifolia is effective as an anti-hyperlipidemic agent.