Investigations on the anti-diabetic profile of the prepared polyherbal tablets

Abstract

DM and its complications are the most common problems in the world today. Even though it is not a contagious disease, bad lifestyle, and unhealthy food habits cause diabetes. The causes for diabetes are bad lifestyles habits, mechanism wise it is caused due to the insufficiency of the insulin secretion of the pancreas and insulin receptor insensitivity. This leads to improper glucose metabolism and reuptake into the muscles. Numerous synthetic drugs are used effectively to treat diabetes. The drugs have those side effects and make their use as limited due to the fear of causing other problems. In this view, the herbs and medicinal plants have been used to treat numerous diseases and are found effective and safer too. There are a lot of herbs that are used to treat diabetes also, and the exact mechanism of action of all those herbs was also investigated and proven. There were chemical leads that were isolated from the herbs and are found to be effective against diabetes. In the present research, the tablet formulation which has the potency to control the blood sugar level in diabetes, which is induced by STZ. This was prepared using the extracts of Psidium guava, Momordica charantia, Ficus religiosa and Piper nigrum and the investigations for the anti-diabetic property revealed that the tablets showed a better activity compared to the standard and individual extract.