ANTI ULCER ACTIVITY OF ETHANOLIC EXTRACTS OF FLOWERS OF LEUCAS ASPERA WILD

Abstract

The ethanolic extract of flowers of Leucas aspera were screened to evaluate anti-ulcer activity in healthy rats, using aspirin induced ulcer method. The leaves of Leucas aspera were collected from the local areas of Thanjavur and shade dried. The dried powdered flowers were extracted from the maceration and soxhlet extraction methods, by using methanol and water. Healthy rats weighing 180-250 gm were taken for the experiment. The anti ulcer activity was noted after drug administration. All data were analysed with one-way ANOVA fallowed by Dunnet’s test. The flower extract of Leucas aspera showed significant anti ulcer activity at a dose of 300 mg/ kg body weight, which was near equivalent to that of ranitidine.