VALUATION OF DIOSPYROS PEREGRINA GUM AS A NOVEL BINDER IN TABLET FORMULATION

Abstract

Various plant gums have been used as binders in tablet formulations. But still finding novel binder for the manufacture of tablets, in pharmaceutical industry. The Diospyros peregrina gum was found its binding property. In the present study Diospyros peregrina gum was employed as a binding agent in Flurbiprofen tablets at concentrations of 2.0, 4.0, 6.0 and 8.0 % w/w, in comparison with Polyvinyl Pyrrolidine (PVP). The granules were evaluated for moisture content, angle of repose, bulk and tapped densities,Carr Index, Hausners ratio. The tablets were evaluated for thickness, weight variation, hardness, friability, disintegration time and dissolution profiles. Studies showed that increase in binding concentration of Diospyros peregrina gum, increases the hardness, increases the disintegration time, decreases the percentage friability and decreases percentage cumulative release. Results obtained indicated that Diospyros peregrina gum performed as good as that of PVP as a binder to Flurbiprofen tablets.