DEVELOPMENT AND VALIDATION OF NABUMETONE BY ISOCRATIC RP- HPLC METHOD

Abstract

Nabumetone is a Non –Steroidal Anti-inflammatory drug which has good analgesic and antirheumatic properties. A new , simple and precise RP-HPLC method was developed and validated for the estimation of Nabumetone in bulk and tablet dosage forms using a hypersil C18,4.6mm×150mm,5µmcolumn from waters with a mobile phase consisting of methanol: phosphate buffer(65:35)at a flow rate of 1.0ml/min.The retention time was 5.01min.Linearity for Nabumetone was in the range of 20-120 µg/ml and the calibration curve was linear(r2=0.999),the recovery was in the range of 99.942-100.15%.The proposed method found to be simple ,precise ,accurate and economical.