Evaluation and comparison of anti-diabetic activity of hydroalcoholic extracts of fresh and dry leaves of Psidium guajava in type-ii diabetes mellitus

Abstract

Psidium guajava is one of the most widely used plant as herbal remedy for the treatment of Diabetes mellitus. In the present study the hydro alcoholic extracts of the fresh and dry leaves of this plant are therapeutically evaluated and compared for anti-hyperglycemic potential against Alloxan induced Diabetes in Rats. The animals were administered with doses of 500mg/kg body weight of extract orally to Alloxan induced rats continuously for 30days, caused significant reduction in the fasting serum blood glucose levels. Among the two extracts fresh leaf extract showed significant anti hyperglycemic activity than the dry leaf extract which nearly produced equal reduction in serum blood glucose levels to that of standard glibenclamide 10mg/kg.