Protective effect of aqueous extract of Aegle marmelos against formaldehyde induced arthritis in rats

Abstract

The present study was aimed to assess the anti arthritic nature of aqueous extract of Aegle marmelos leaves (AEAM) against formaldehyde induced arthritis in rats. The degree of inflammation was evaluated by hind paw swelling and increase in paw diameter. AEAM showed significant changes in paw swelling, paw diameter and percent inhibition of paw volume. The results of the current investigation concluded AEAM possess a significant anti arthritic activity against formaldehyde induced arthritis model and justifying its therapeutic role in arthritic condition. The observed anti arthritic activity may be due to the presence of phytoconstituents such as alkaloid, saponins and flavonoids.