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Abstract

The object of this research work was to formulate, develop and evaluate the Sustained Release (SR) Tablets of anti hypertensive drug (Carvedilol). The tablets were prepared relatively small dose of 20 mg by direct compression method. For the Sustained release formulation the dissolution time of the tablet must be optimized in order to have a prolonged release of drug in the dissolution profile. The dissolution time is managed by using polymers like Hydroxy propyl methyl cellulose and polyethylene oxide in the formulation. These trails were optimized by incorporating varying composition of Lactose, Micro crystalline cellulose as diluents, Magnesium strate as gildent. The different excipients were tested for their compatibility with anti hypertensive drug (Carvedilol), which revealed that there was no chemical and physical interaction occurred. The preformulation parameters such as bulk density, tapped density, compressibility index and hausner’s ratio were analysed for prepared granules before compression. The thickness, hardness, friability, weight variation and drug content uniformity was evaluated for tablets. The effect of this variable on the drug release profile of carvedilol was also studied. The in-vitro drug release were performed in the USP Apparatus-II (Paddle) using 0.1N HCl as a dissolution media at 50rpm speed and temperature of 370C ± 0.50C. The sampling was done at periodic time intervals of 1, 2, 4, 8, 12 and 16 hrs, and was replaced with equal volume of dissolution media after each with drawl. The cumulative amount of drug release at different time interval was estimated using UV method. These results indicate that the selected formulation was stable during the period of accelerated stability studies. All evaluated formulation results was found to be satisfied.

Keywords

Carvedilol sustained release tablets HPMC

Article Details

How to Cite
Gutti, S. P., & kalra, M. (2012). Formulation and evaluation of sustained release tablets of carvedilol . International Research Journal of Pharmaceutical and Applied Sciences, 2(4), 78-83. Retrieved from https://scienztech.org/index.php/irjpas/article/view/340