EVALUATION OF TOPICAL ANTI-INFLAMMATORY EFFECT OF AZADIRACHTA INDICA LEAF EXTRACT

Abstract

This study aimed to evaluate the possible anti-inflammatory effects of separate ointment formulations of three extracts of Azadirachta indica (A. indica) for topical administration. It also compared the prepared formulation with a standard ointment in the market (Volini gel) by using the carrageenan induced hind-paw model and skin punch biopsy method in experimental rats by topical application. The petroleum ether, chloroform and alcohol extracts of the leaves of A. indica were prepared into an ointment, which contained 5% of each extract separately in a cream base. Among the prepared formulations of the plant, the petroleum ether extract of A. indica showed the maximum edema inhibition, which was similar to that of Diclofenac gel. The inhibition of the inflammation in both the models suggests that A. indica may be used for managing the inflammatory conditions.