FORMULATION AND EVALUATION OF SUSTAINED RELEASE ACECLOFENAC TABLETS

Abstract

The purpose of this research was to develop a matrix type tablets containing drug Aceclofenac with different ratios of hydrophilic (hydroxyl propyl methyl cellulose) and hydrophobic (ethyl cellulose) polymers. The physicochemical compatibility of the drug and the polymers studied by infrared spectroscopy suggested absence of any incompatibility. Formulated sustained release Aceclofenac tablets were physically evaluated with regard to thickness, weight variation, drug content, friability, hardness. All prepared formulations indicated good physical stability. In-vitro dissolution studies of formulations were performed by using USP-I dissolution apparatus. The results followed the release profile of Aceclofenac followed zero order kinetics. However, the release profile of the optimized formulation F2 has r2 value 0.998 for zero order. To conclude, hydroxy propyl methyl cellulose at a concentration ratio of 4: 3 is suitable for preparing sustained release matrix tablets of Aceclofenac.